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Hims and Hers Super Bowl Ad Sparks Controversy Over Weight Loss Drugs The New York Times Before 2025, there were zero official protocols for coming off a GLP 1 medication. Not because doctors were withholding information but because the clinical guidelines simply didn't exist yet. The AACE 2025 20141 Figure 2, Health Canada Approval Timeline for GLP 1 Receptor Agonists by Marketed Date and NOC Dates Formulary Management of Sodium Glucose Cotransporter 2 Inhibitors and Glucagon Like Peptide 1 Receptor Agonists NCBI Bookshelf GLP 1s and addiction: lots of promise, but not yet a single robust RCT with a clear clinical outcome. What we do know: Strong preclinical evidence suggests GLP 1RAs reduce drug alcohol intake Sebastian