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Treating Diabetes with Lizard Spit
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The discovery of a digestion-slowing hormone in the Gila monster's venom paved the way for Ozempic. When a Gila monster named Pebbles needed medicine in return, a pharmaceutical chemist pivoted to help
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The connection is real—but it's a bit more specific than it's often presented. The Gila monster produces a peptide in its venom called exendin-4, which mimics a human hormone involved in blood
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NephMadness 2024: Animal House Region – AJKD Blog
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GLP-1 receptor agonists got their start in an unlikely place: the mouth of a lizard. A peptide that was discovered in Gila monster saliva, called exendin-4, was found to mimic the action
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The Gila Monster + GLP-1: How a Lizard Changed Medicine
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A. Amino acid sequence comparison for exenatide (synthetic exendin-4)
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